CHOZN® Products and Services

Biopharmaceutical Expression Systems

Production Lines, Media and Feeds Optimized for the Demands of Biopharmaceutical Manufacturing

We offer multiple levels of support for your biopharmaceutical expression systems needs with a focus on increasing production titer and decreasing development timelines. In addition to our long history of reliability in supplying high grade critical raw materials, our products and services are backed by expert technical support by Ph.D. level scientists and comprehensive protocols for ease of use. Decrease your time to market and costs by leveraging the CHOZN® platform!

CHOZN® Platform
CHOZN® Cell Lines CHOZN® & UCOE® Combined Platform Cell Line Engineering and Development CHOZN® Media and
Feed Systems
CompoZr® ZFNs
• CHOZN® GS-/-
  cell line
• CHOZN® CHO
  K1 cell line
• CHOZN® DHFR-/-
  cell line
• UCOE® GS
  Expression Vector
• pCGS3.2
  expression vector
• Accelerate your cell line development by increased efficiency of isolating high producing clones with 8-fold more clone candidate pools and double number of clones expressing more than 3g/L
• Increase cell line development success with hard-to-produce molecules
• Achieve high and stable titers to expedite your cGMP manufacturing with fewer resources
• UCOE® GS Expression Vector
• Recombinant cell line
  development
• Gene knockout
• Targeted integration
• EX-CELL Advanced
  Medium and feed
• CD CHO Fusion
• CHO Cloning Medium
• Custom ZFNs
  engineered to any
  gene target

CHOZN® Cell Lines

We have created a series of zinc finger nuclease (ZFN) modified CHO cell lines with characteristics that are attractive in a platform cell line to biopharmaceutical developers and manufacturers. 

CHOZN® & UCOE® Combined Platform

The UCOE (Ubiquitous Chromatin Opening Elements) technology uses naturally occurring DNA sequences capable of creating and maintaining open chromatin to enable high, stable transgene expression, regardless of the integration site. When included in a plasmid alongside the transgene of interest, these UCOE elements greatly increase the number of high expressing clones that can be isolated within a single cell line development process.

Cell Line Engineering and Development

Our CHOZN® platform development experts leverage several molecular biology technologies, most notably CompoZr® Zinc Finger Nuclease Technology, to engineer mammalian lines for customers to use in bioproduction. Our mission is to facilitate customer’s research and manufacturing needs through application of our experience in cell engineering technologies. We can also perform custom cell line development of recombinant cell lines in our CHOZN® GS CHO cell line. Alternatively, we can perform the work in your host cell line.

CHOZN® Media and Feed System

Our new EX-CELL® Advanced media and feed system was designed and optimized for the CHOZN® GS cell line using multiple molecules, including mAbs and fusion proteins, resulting in 3-5 fold increases in therapeutic productivity while maintaining critical protein attributes. The EX-CELL® Advanced system has been shown to support in excess of 5g/L in CHOZN® platform cell line.

CompoZr® Zinc Finger Nucleases

Zinc Finger Nucleases (ZFN) are a class of engineered DNA-binding proteins that facilitate targeted editing of the genome by creating double-strand breaks in DNA at user-specified locations. ZFN technology allows for easy creation of novel cell lines, including CHO, with precise and heritable gene additions, deletions or modifications.