New Products for Chemical Synthesis

Mass Spectrometry-Cleavable Crosslinkers
A suite of new sulfoxide-containing crosslinkers (909602,909610,909599,909688) are ideal tools for analysis of protein-protein interactions (PPIs). Each homobifunctional linker contains an amino acid-targeting reactive group, a spacer region, and two symmetrical C-S cleavable bonds that yield tagged peptides for unambiguous identification via collision-induced dissociation using tandem MS. Such linkers will find wide utility in the elucidation of PPIs, protein complex architecture, and structural dynamics.

FastWoRX Separation Technology
FastWoRX products are hydrophobic powders that absorb most organic compounds. With them, liquid-liquid extraction (LLE) for reaction workups can be replaced by a simple filtration or magnetic separation. Products are available for filtration (FASTWORX-S) or magnetic separation (FASTWORX-M).

Air-stable Ni Catalysis

Ni(COD)(DQ) (912794) is an air- and thermally stable Ni(0) precatalyst developed by the Engle lab at The Scripps Research Institute. This 18-electron complex has a unique stability profile allowing for easy reaction setup outside an inert atmosphere. Transformations such as the Suzuki-Miyaura coupling, borylation of aryl halides, and alkene hydroarylation have been demonstrated.

Synthetic Reagents

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904090 (6R,7aR)-3-amino-8,8-dimethyltetrahydro-4H-3a,6-methanobenzo[d]oxazol-2(3H)-one hydrochloride 95% New
ALD00612 (S)-N-(1-(Dimethylamino)-3-phenylpropan-2-yl)acetamide ≥95% New
913383 1,3-Dimethylimidazoyl-2-ylidene borane ≥95% New
FASTWORX-M FastWoRX-M Magnetic Powder  New
FASTWORX-S FastWoRX-S Sorbent Powder New
912514 N-Nitrosaccharin New
911178 PS-750-M solution, 3 wt. % in H2O New
912026 5-((Triisopropylsilyl)ethynyl)-dibenzo[b,d]thiophenium triflate ≥95% New

Chemical Biology

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910546 (S,R,S)-AHPC-C6-PEG3-butyl alkyne ≥95% New
910600 (S,R,S)-AHPC-PEG2-butyl CO2H ≥95% New
910554 (S,R,S)-AHPC-PEG6-butyl CO2H ≥95% New
909688 Alkyne-A-DSBSO crosslinker ≥95% New
906107 (9-Aminononyl)triphenylphosphonium bromide 90% New
909629 Azide-A-DSBSO crosslinker ≥95% New
914134 5-(Biotinamido)pentylamine TFA Salt ≥95% New
914916 Biotin-SS-tyramide ≥95% New
913979 Biotin-Thalidomide ≥95% New
914711 8-Biotinylamido-3,6-dioxaoctanoic acid ≥95% New
914460 1-Biotinyl-3,6-dioxa-8-octaneamine hydrochloride ≥95% New
912654 N-(3,5-Bis(trifluoromethyl)phenyl)-2-chloroacetamide ≥95% New
909610 BMSO crosslinker ≥95% New
902675 BocNH-PEG6-acid New
911798 N-(4-Bromophenyl)-N-phenylacrylamide ≥95% New
911690 C5 Lenalidomide ≥95% New
911739 C5 Lenalidomide-PEG1-NH2 hydrochloride ≥95% New
911747 C5 Lenalidomide-PEG3-NH2 hydrochloride ≥95% New
911704 C5 Lenalidomine-C3-NH2 hydrochloride ≥95% New
912131 2-Chloro-1-(6-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one ≥95% New
916080 Diethyl-4-cyclohexyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate ≥95% New
910074 27,27-Dimethyl-25-oxo-3,6,9,12,15,18,26-heptaoxaoctacosanoic acid ≥95% New
914487 2-(Diphenylphosphanyl)benzamide ≥95% New
909602 DSSO crosslinker ≥95% New
914002 Fmoc-Asp(CSY)-OH ≥95% New
910023 3,6,9,12,15,18-Hexaoxahexacos-25-ynoic acid New
913839 2-Methylnicotinic acid imidazolide New
913588 O-(2-Nitrobenzyl)-L-tyrosine hydrochloride ≥95% New
910066 6-(2-(2-(Oct-7-yn-1-yloxy)ethoxy)ethoxy)hexanoic acid ≥90% New
914312 N3-TFBA-O2Oc ≥98% New

Catalysis

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913200 (R)-BIDIME ≥97% New
912719 (S)-BIDIME ≥97% New
911836 Chloro(1-tert-butyl-1H-inden-1-yl)(tri-tert-butylphosphine)palladium New
910422 Diacetatobis(tricyclohexylphosphine)palladium(II) New
913391 2-[2-Fluoro-4-(trifluoromethyl)phenyl]-5-(trifluoromethyl)pyridine New
910430 Grubbs Catalyst® M220 Umicore New
903647 1-Heptyl-2-norbornene ≥95% New
914789 iPr-NDI ≥95% New
912948 Ir[FCF3(CF3)ppy]2(dtbbpy)PF6 New
911844 (Me4Phen)NiCl2 New
Z744037 Multi-Vial Holder Penta - 4mL New
Z744038 Multi-Vial Holder Quad - 8mL New
912794 Ni(COD)(DQ) ≥95% New
913154 1,10-Phenanthroline nickel (ll) dibromide New
912468 (2S,3S)-iPr-BIDIME ≥95% New
908894   Rhodium(III) oxide/Platinum(IV) oxide hydrate New
905348 Rh2(R-p-Ph-TPCP)4 New
905321 Rh2(R-TCPTAD)4 New
905313 Rh2(S-TCPTAD)4 New
912255 sBOX(tBu) ≥95% New
912778 sBOX(iPr) ≥95% New
912646 tBuBrettPhos Pd G6 bromide New
912883 tBuBrettPhos Pd G6 TES New
910228 1,3,5,7-Tetramethyl-2,4,8-trioxo-6-(2-bromophenyl)-6-phosphaadamantane ≥95% New