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U8882 Sigma-Aldrich

Ubiquitin-Carrier Protein H5c human

≥95% (SDS-PAGE), recombinant, expressed in E. coli (GST-tagged), solution

Synonym: UbcH5c

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience,
Quality Level   200
biological source   human
recombinant   expressed in E. coli (GST-tagged)
assay   ≥95% (SDS-PAGE)
form   solution
mol wt   47 kDa
application(s)   ligand binding assay: suitable
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... UBE2D3(7323)

Description

General description

Manufactured for Sigma by Boston Biochem., Inc.

Application

Ubiquitin-Carrier Protein H5c human may be used to study ubiquitin-proteasome system and its role in pathogenesis of human diseases.

Biochem/physiol Actions

Mediates the degradation of a myriad of short-lived regulatory proteins including the tumor suppressor p53 in the presence of E6/E6-AP or MDM2, the c-Fos transcription factor, and the signal-induced ubiquitination of IκBα, UBC5 is an essential gene in yeast.

Ubiquitin-Carrier Protein H5c human also referred to as UbcH5c is a recombinant protein that interacts with ZIPK and stimulate its ubiquitination and hence facilitates in regulating ZIPK accumulation in promyelocytic leukemia protein nuclear body (PML-NBs).

Physical form

Solution in 50 mM HEPES, pH 7.6, 50 mM NaCl, 1 mM DTT in 10% glycerol.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
Peer-Reviewed Papers
15

References

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