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U8757 Sigma-Aldrich

Ubiquitin-Carrier Protein H5b human

≥95% (SDS-PAGE), solution

Synonym: UbcH5b

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience,
biological source   human
recombinant   expressed in E. coli (GST-tagged)
assay   ≥95% (SDS-PAGE)
form   solution
mol wt   47 kDa
application(s)   ligand binding assay: suitable
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... UBE2D2(7322)

Description

General description

Manufactured for Sigma by Boston Biochem., Inc.

Application

Ubiquitin-Carrier Protein H5c human was used to study the role of ubiquitin-proteasome system in pathogenesis of human diseases.

Biochem/physiol Actions

Mediates the degradation of a myriad of short-lived regulatory proteins including the tumor suppressor p53 in the presence of E6/E6-AP or MDM2, the c-Fos transcription factor, and the signal-induced ubiquitination of IκBα, UBC5 is an essential gene in yeast.

Ubiquitin-Carrier Protein H5b human also referred to as UbcH5b is a recombinant protein that enhances the activation of NF-κB via ubiquitination as well as facilitates in proteasome-mediated degradation of its inhibitor κBα. It also assists in regulating p53 levels by ubiquitination.

Physical form

Solution in 50 mM HEPES, pH 8.0, 100 mM NaCl, 10% glycerol

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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