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RES3193T-A7 SAFC

Tromethamine

PharmaGrade, Manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production, suitable for cell culture, Meets USP, EP, JPC, BP testing specifications.

Synonym: Tris, Tromethamine

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Properties

Related Categories Biochemicals and Reagents, Biological Buffers, Good’s Buffers, PharmaGrade Buffers
Quality Level   400
biological source   synthetic
Agency/Method   USP
product line   PharmaGrade
form   powder
application(s)   cell culture | mammalian: suitable
impurities   Endotoxin, microbial, and heavy metals; tested
suitability   suitable for manufacturing use
foreign activity   Cytotoxicity, DNase, NICKase, RNase, and Protease; tested
SMILES string   NC(CO)(CO)CO
InChI   1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
InChI key   LENZDBCJOHFCAS-UHFFFAOYSA-N

Description

General description

PharmaGrade products are manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. For more information on the PharmaGrade Program, visit sigma-aldrich.com/safc-pharmagrade.

Application

Tromethamine is a commonly used biological buffer which is also referred to as Tris or Trizma. Tris as a buffer has very broad usage in diagnostics and downstream purifications. The pKa of Tris is 7.77 which corresponds closely to a physiological pH of 7.36.

Tromethamine is used in biopharmaceutical buffer formulations (both upstream and downstream), electrophoresis separations and diagnostic reagent formulations. Tromethamine is especially useful in downstream purification processes.

Packaging

Product is available in the following package sizes:
RES3193T-A701X: 100 gm container
RES3193T-A703X: 5 kg container
RES3193T-A705X: 25 kg container
RES3193T-A706X: 50 kg container

Linkage

Enhanced Quality Product Documentation on PharmaGrade Tromethamine, USP, EP, JPC, BP Tested

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
TY2900000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

pHast Pack
Protocols & Articles

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Peer-Reviewed Papers
15

References

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