PharmaGrade, Manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production, suitable for cell culture

Synonym: β-Hydroxy-4-morpholinepropanesulfonic acid, 3-Morpholino-2-hydroxypropanesulfonic acid, MOPSO

  • CAS Number 68399-77-9

  • Empirical Formula (Hill Notation) C7H15NO5S

  • Molecular Weight 225.26

  •  Beilstein/REAXYS Number 1109697

  •  EC Number 269-989-6

  •  MDL number MFCD00009629

  •  PubChem Substance ID 329824238

  •  NACRES NA.21



Related Categories Biochemicals and Reagents, Biological Buffers, Good’s Buffers, PharmaGrade Buffers
Quality Level   400
biological source   synthetic
Agency/Method   non-compendial
product line   PharmaGrade
form   powder
application(s)   cell culture | mammalian: suitable
useful pH range   6.2 - 7.6
pKa    6.9
suitability   suitable for manufacturing use
foreign activity   Cytotoxicity, DNase, NICKase, RNase, and Protease; tested
SMILES string   OC(CN1CCOCC1)CS(O)(=O)=O
InChI   1S/C7H15NO5S/c9-7(6-14(10,11)12)5-8-1-3-13-4-2-8/h7,9H,1-6H2,(H,10,11,12)


General description

PharmaGrade products are manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. For more information on the PharmaGrade Program, visit


MOPSO is a biological buffer also referred to as a second generation “Good′s” buffer which displays improved solubility compared to traditional “Good′s” buffers. The pKa of MOPSO is 6.9 which make it an ideal candidate for buffer formulations which require a pH slightly below physiological to maintain a stable environment in solution. MOPSO is considered to be non-toxic to culture cell lines and provides high-solution clarity.

MOPSO can be used in cell culture media, biopharmaceutical buffer formulations (both upstream and downstream) and diagnostic reagents.


Product is available in the following package sizes:
RES0196M-B701X: 100 gm container
RES0196M-B702X: 1 kg container
RES0196M-B704X: 10 kg container


According to Ferreira, et al., MOPSO can have a strong interaction with iron in solution. Based on this citation, it is recommended to use plastic-coated or PTFE-coated utensils when working with this chemical.


Enhanced Quality Product Documentation on PharmaGrade MOPSO

Safety & Documentation

Safety Information

GHS07  GHS07
Signal word 
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

pHast Pack
Protocols & Articles

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