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H7158 Sigma-Aldrich

Heat Shock Protein 60 human

recombinant, expressed in E. coli, buffered aqueous solution, ≥95% (SDS-GE)

Synonym: HSP 60

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Biology, Cell Culture, Cell Signaling Enzymes,
biological source   human
recombinant   expressed in E. coli
assay   ≥95% (SDS-GE)
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... HSPD1(3329)

Description

General description

The gene HSP60 (heat shock protein 60) is mapped to human chromosome 2q33.1. It is a mitochondrial protein. HSP60 is induced under various stress conditions, including DNA damage, oxidative stress and heat shock. HSP60 is also referred to as HSPD1 (heat shock protein family D member 1).

Biochem/physiol Actions

HSP60 (heat shock protein) works together with the cochaperonin HSP10 to allow protein folding of mitochondrial-imported proteins. It is involved in brain myelination and pathogenesis of hypomyelinating neurodegenerative disease. It also enhances proinflammatory response in cells, including macrophages, dendritic cells and endothelial cells. Mutation in HSP60 is linked with hereditary spastic paraplegia (SPG13).

Physical form

Solution in Dulbecco′s buffered saline

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

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Peer-Reviewed Papers
15

References

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