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  • 1.08386 - Tris(hydroxymethyl)aminomethane

1.08386 SAFC



Synonym: 2-Amino-2-(hydroxymethyl)-1,3-propanediol, THAM, Tris base, Trometamol

  • CAS Number 77-86-1

  • Linear Formula NH2C(CH2OH)3

  • Molecular Weight 121.14

  •  Beilstein/REAXYS Number 741883

  •  MDL number MFCD00004679

  •  EC Index Number 201-064-4



Related Categories APIs (Active Pharmaceutical Ingredients) and Excipients, Biomolecule Liquid Dosage Forms, Biopharmaceutical Manufacturing, Biopharmaceutical Process Development and Manufacturing, Chromatography for Biopharmaceutical Manufacturing,
Agency/Method   BP
  Ph. Eur.
Quality Level   500
vapor pressure   0.0267 hPa ( 20 °C)
product line   Emprove® Essential
potency   >5000 mg/kg LD50, oral (Rat)
  >5000 mg/kg LD50, skin (Rat)
pH   10.2-10.6 (20 °C, 6 g/L in H2O)
useful pH range   7 - 9
pKa (25 °C)   8.1
bp   219-220 °C/10 mmHg (lit.)
  219-220 °C/13.3 hPa
mp   167-172 °C (lit.)
solubility   678 g/L
density   1.35 g/cm3 at 23 °C
bulk density   840 kg/m3
SMILES string   NC(CO)(CO)CO
InChI   1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
storage conditions   no restrictions.


General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.


Tris(Hydroxymethyl)aminomethane (Trometamol) is a commonly used buffer component in biomolecule downstream chromatography steps as well as final liquid formulation.
The specification of the product is part of the Emprove® Material Qualification Dossier and can be found under "General Properties".

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Emprove® Dossiers

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Protocols & Articles

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