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transformation/transcription domain-associated protein
Synonyms PAF350/400, PAF400, STAF40, TR-AP, Tra1
Species Human (8295) , Species Mouse (100683) , Species Rat (288471) , Species Zebrafish (557263) , Species Horse (100059214) , Species domestic cat (101083988) , Species dog (479747) , Species chicken (416440) , Species cow (507169) , Species sheep (101103618) , Species domestic guinea pig (100723821) , Species naked mole-rat (101722141)
Summary: This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]